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Mississippi State, Florida State, and Auburn held onto the top three spots in the second week of the CFP. Ole Miss fell out of the top four after their loss over the weekend, replaced by Oregon. Ole Miss is the highest ranked 2-loss team at #11.
From the Big 12, we see #6 TCU, #7 Kansas State, #12 Baylor, #15 Oklahoma, and #23 West Virginia.
Unbeaten Marshall is still not in the poll and West Virginia is the only 3-loss team in the poll.
| Rank | Team | Last week | Week 10 result | Toughest opponent left (per F/+) | If the season ended today ... |
| 1 | Mississippi State (8-0) | 1 | Won 17-10 vs. Arkansas | Ole Miss | Sugar Bowl vs. Oregon |
| 2 | Florida State (8-0) | 2 | Won 42-31 at No. 25 Louisville | Miami | Rose Bowl vs. Auburn |
| 3 | Auburn (7-1) | 3 | Won 35-31 at No. 4 Ole Miss | Alabama | Rose Bowl vs. Florida State |
| 4 | Oregon (8-1) | 5 | Won 45-16 vs. Stanford | Utah | Sugar Bowl vs. Mississippi State |
| 5 | Alabama (7-1) | 6 | Idle | Auburn | Orange Bowl |
| 6 | TCU (7-1) | 7 | Won 31-30 at No. 20 WVU | Kansas State | New Year's bowl |
| 7 | Kansas State (7-1) | 9 | Won 48-14 vs. Oklahoma St. | TCU | New Year's bowl |
| 8 | Michigan State (7-1) | 8 | Idle | Ohio State | New Year's bowl |
| 9 | Arizona State (7-1) | 14 | Won 19-16 vs. No. 17 Utah | Notre Dame | New Year's bowl |
| 10 | Notre Dame (7-1) | 10 | Won 49-39 at Navy | Louisville | New Year's bowl |
| 11 | Ole Miss (7-2) | 4 | Lost 35-31 vs. No. 3 Auburn | Mississippi State | New Year's bowl |
| 12 | Baylor (7-1) | 13 | Won 60-14 vs. Kansas | Oklahoma | |
| 13 | Nebraska (8-1) | 15 | Won 35-14 vs. Purdue | Wisconsin | |
| 14 | Ohio State (7-1) | 16 | Won 55-14 vs. Illinois | Michigan State | |
| 15 | Oklahoma (6-2) | 18 | Won 59-14 at Iowa St. | Baylor | |
| 16 | LSU (7-2) | 19 | Idle | Alabama | |
| 17 | Utah (6-2) | 17 | Lost 19-16 at No. 14 Arizona St. | Oregon | |
| 18 | UCLA (7-2) | 22 | Won 17-7 vs. No. 12 Arizona | USC | |
| 19 | Arizona (6-2) | 12 | Lost 17-7 at No. 22 UCLA | Arizona State | |
| 20 | Georgia (6-2) | 11 | Lost 38-20 vs. Florida | Auburn | |
| 21 | Clemson (6-2) | 21 | Idle | Georgia Tech | Orange Bowl |
| 22 | Duke (7-1) | 24 | Won 51-48 at Pittsburgh | Virginia Tech | |
| 23 | West Virginia (6-3) | 20 | Lost 31-30 vs. No. 7 TCU | Kansas State | |
| 24 | Georgia Tech (7-2) | NR | Won 35-10 vs. Virginia | Clemson | |
| 25 | Wisconsin (6-2) | NR | Won 37-0 at Rutgers | Nebraska |