A group of writers are currently going through a mock NCAA tournament selection process, and earlier today they released their mock seed list. The obvious problem here is that there is still almost a month left in the season, and, for example, Duke and North Carolina and Kansas and Missouri have only played each other once so far, with the second meeting likely dramatically impacting the seeding.
But beyond that, I noticed Missouri as a 1 seed and immediately thought about their strength of schedule. Overall (note: all SOS values are according to KenPom) it's not terrible (72), but their non conference SOS of 313 is historically bad for a team that is talked about as a one seed. How bad? Let's take a look.
Examining it a bit more closely, Missouri's non-conference SOS of 313 is the worst on this list by nearly 90 spots. Their overall SOS of 72 would currently be the second weakest on this list next to only 2004 Stanford, who went undefeated until the final regular season game. To put it into perspective, their overall SOS is even worse than the 2006 Memphis team, who played in the 16th ranked conference. With (at least) three games against top 40 teams left Missouri's overall SOS will likely rise. They certainly are a good team, ranked 8th in KenPom and having lost only two games, but the fact remains that strength of schedule wise Missouri would have the weakest profile for a #1 seed since 2003.